Endocrine Abstracts

Introduction: Increased insulin-like growth factor 1 (IGF-1) levels in patients with acromegaly are associated with clinical and radiological osteoarthritis (OA). We aimed to elucidate whether serum IGF-1 levels differ in patients with primary OA as compared to healthy controls and whether genetic variants known to affect serum IGF-1 levels are also associated with primary OA.Methods: Patients from the GARP study with familial generalized OA (n=...

Purpose: The condition of pituitary apoplexy contains the clinical spectre from life-threatening emergency to a condition with chronic symptoms and self-limiting course, which partly determines diagnostic delay and management. Outcome evaluation of course and management of pituitary apoplexy is hampered by the diverse presentation of this condition and requires appraisal. This study aimed to describe the patient journey, clinical presentation and management of various types of...

Objective: Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) excess results in both reversible and irreversible damage to the skeleton, and includes increased vertebral fracture (VF) risk in the presence of normal BMD. The prevalence of VFs is approximately 60% in controlled acromegaly patients, and these VFs can progress during short-term follow-up. We aimed to identify the course of VFs and their associated risk factors in a cohort of acromegaly patients in long-t...

Introduction: Fibrous dysplasia (FD)/McCune Albright Syndrome (MAS) is a rare disorder affecting bone and hormonal glands. In FDMAS patients, autonomous GH hypersecretion (GH+) is the most common endocrinopathy after Precocious Puberty and has a great impact on the morbidity and complication rate in patients with craniofacial fibrous dysplasia. However clinical and biochemical features of GH over secretion can be subtle and awareness is warranted. We aimed to explore the GH/IG...